Diethylene glycol, also known as DEG with the formula C4H10O3, is a colorless, low volatility liquid commonly used as a solvent, chemical intermediate, and component in antifreeze and heat transfer fluids. In equipment and processing systems, its presence may affect O-rings, rubber seals, gaskets, and certain plastic materials, making compatibility evaluation important to limit swelling or degradation. Although considered relatively low in acute toxicity, exposure can cause skin and respiratory irritation. Proper storage, handling procedures, and appropriate PPE are recommended.

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